Overactive bladder and Urge Incontinence

The "Overactive bladder" syndrome consists of any 2 of these 3 symptoms:

Urinary Urgency Difficulty in controlling the bladder when struck by the urge to "go"

Urinary Frequency Going too many times a day. This is usually defined as more than 8 times a day. But one also needs to take account of the type and amount of fluid drunk, amount passed each time and level of urgency to decide if there really is a problem.

Urinary Incontinence Urinary leakage presaged by a sudden desire to void.

Sometimes, these same symptoms are caused by stones, infections or even some medical conditions . Sometimes there is no known cause (idiopathic). A few tests and xrays are usually done to make sure one's symptoms are not due to a treatable condition before it is deemed "idiopathic".

We treat our patients with overactive bladders with a combined bladder training regime. Under the purview of a urologist, a continence nurse will train, supervise and monitor patients on behavioral techniques that include education, dietary changes, bladder training and Pelvic floor muscle training, biofeedback or functional electrical stimulation.

We also use medications to relax the bladder. Sometimes, a few different medications may be tried before the best one is found for a specific individual. Unfortunately, many of these medications do create undesirable side effects; therefore, frequent communication between doctor and patient is essential to get the best results with the least side effects.

More invasive therapy or complex surgical treatments are available for patients with overactive bladder who do not respond to medical therapy. Such patients should undertake urodynamic testing before alternative or surgical therapy is considered

Dr Quek is a pioneer in using Botox for urge incontinence and lower urinary tract dysfunction and has conducted several clinical trials using Botox in the lower urinary tract .The off label use of Botox may be considered in selected cases after failure of medical therapy.

MEDICAL TERMS

BLADDER TRAINING

Perhaps the best first-line approach for any form of incontinence is a combination of Kegel exercises and bladder training. In one study, women who used this combination approach experienced an average 50% reduction in incontinence episodes, with nearly 40% of them achieving complete continence. It was equally effective for urge, stress, or mixed incontinence.

Patients start by planning short intervals between urinations and then gradually progressing with the ultimate goal of voiding every three to four hours. Bladder retraining gradually prolongs the time between visits to the toilet and is usually taught with urge suppression strategies. At Pearllyn Quek Urology, patients undergo a supervised 3 month program that has a proven success rate of 80%. Adjuncts like medications, electrical stimulation or biofeedback may be used. Patients record their progress on a voiding diary and goals are laid out and regularly reviewed. With or without medication, bladder training has helped many people overcome urinary urgency, frequency and incontinence and is thought to have a longer lasting impact than medications alone.

These bladder diaries show the improvement in urinary frequency and voided volumes before (left chart) and after(right chart) bladder retraining.

PELVIC FLOOR MUSCLE TRAINING

Perhaps the best first-line approach for any form of incontinence is a combination of Kegel exercises and bladder training. In one study, women who used this combination approach experienced an average 50% reduction in incontinence episodes, with nearly 40% of them achieving complete continence. It was equally effective for urge, stress, or mixed incontinence.

Studies also reported that between 50% and 75% of patients who perform only pelvic floor exercises experience a substantial improvement in their symptoms, including elderly people who have had the problem for years.

Kegel’s or Pelvic floor muscle exercises are designed to strengthen the muscles of the pelvic floor that support the bladder and close the sphincters. Dr. Kegel first developed these exercises to assist women before and after childbirth, but they are very useful in helping to improve continence for both men and women. Studies indicate that such exercises are very effective, even for men recovering from surgery for prostate cancer.

Kegel exercises are particularly useful for the following:

Stress incontinence. Some experts believe that Kegel exercises should be the primary treatment for stress incontinence.

Urge incontinence. They can also be helpful for urge incontinence in cases that are not caused by nerve damage. In one study, 85% of women reported satisfaction with this program.

At Pearllyn Quek Urology, your pelvic floor contraction efforts will be assessed and graded before starting your PFMT program. This grading, along with your clinical progress will be reviewed over 3 months.

Rating

Contraction

Duration

0

None

None

1

Flicker

None

2

Slight Squeeze

Not Sustained

3

Moderate Squeeze

2 to 3 Secs.

4

Good Squeeze

3 to 5 Secs.

5

Strong Squeeze

More than 5 Secs.

Grading of the pelvic floor muscle using the modified Oxford Scale(Laycock 1994)

It will usually take 3 months before a patient sees significant improvement.

Incontinence will return to its original severity if these exercises are discontinued, so commitment to the program must be high and possibly life-long.

These bar charts show how the majority of our patients improve from Grades 0-3 (poor or unsustained contractions) to grades 3-5 (dark blue bars) at the end of our 3 months program.

Dark blue bars – After PFMT
Light blue bars – Before PFMT
Grade 1 = Mild, occasional stress incontinence that does not require surgery
Grade 2 = Moderate stress incontinence often requiring surgery
Grade 3 = Severe daily stress incontinence definitely requiring surgery

This bar chart shows how the majority of patients undergoing our pelvic floor training are cured (dry) or improved (shifted to Gd 1) compared to before (light blue bars)

BIOFEEDBACK

Biofeedback involves using visual, sound or tactile feedback to re-inforce teaching of physiological functions. In patients unable to do proper Kegel’s exercise, biofeedback is utilized with a graphical analysis of pelvic muscle contractions conveyed via a small vaginal probe (above). The results can be analyzed graphically and compared over time to ensure that you are improving. At Pearllyn Quek Urology, we have a scheduled program for biofeedback that allows us to monitor our patients and ensure that pelvic floor strengthening and clinical improvement is achieved.

FUNCTIONAL ELECTRICAL STIMULATION

For patients with weak pelvic floor muscles, electrical stimulation is usually added to supplement other treatments. Electrical stimulation involves placing a small, transvaginal probe that provides a very low amplitude, painless electrical current to stimulate the muscles by creating a rhythmic contraction of the pelvic floor musculature. This technique helps with the training and response that patient get with pelvic floor exercises.

Small amplitude , painless electrical current is also utilized to treat urinary urgency, frequency and pelvic pain. At Pearllyn Quek Urology, we have a scheduled program for electrical stimulation that allows us to monitor our patients and ensure that pelvic floor strengthening and clinical improvement is achieved.

URODYNAMIC STUDY (UDS)

This is a test that measures the pressure in the bladder and the flow of urine through the urethra. It provides information about how much urine the bladder can hold and allows your doctor to assess the efficacy of your bladder in storing and voiding urine. Sometimes, urodynamics is done together with x-ray screening, where live images produced on a TV monitor show the doctor what is happening when your bladder is filling and emptying. The screening is known as video-urodynamics (VUDS). Both routine (without x-ray) and video-urodynamics involve the insertion of very fine tubes into the urethra and rectum. The study forms part of the total assessment of your bladder problems from which your doctor can plan appropriate therapy.

BOTOX

this is the most common commercial form of Botulinum A Toxin. Botulinum A Toxin is a toxin purefied from bacteria. It prevents the nerve endings in muscles from sending the signals to contract. As a result, muscles become paralysed, flaccid and may shrink in size from disuse.This fact is exploited by plastic surgeons to well known effect. It is also used by neurologists who treat patients with muscle spasticity. The amount of paralysis is dose related. It takes about 28,000 units of toxin to kill an adult. Doses used for medical purposes range from 20-300 units and are very safe. The use of Botulinum A Toxin for urological conditions is not FDA approved yet.

This is because trials with numbers large enough to provideproof of effect are yet to be concluded. However, it is used in Europe and Asia, usually in the context of clinical trials, to treat urge incontinence and voiding disorders with very positive results.

BIOFEEDBACK

Biofeedback involves using visual, sound or tactile feedback to re-inforce teaching of physiological functions. In patients unable to do proper Kegel’s exercise, biofeedback is utilized with a graphical analysis of pelvic muscle contractions conveyed via a small vaginal probe (above). The results can be analyzed graphically and compared over time to ensure that you are improving. At Pearllyn Quek Urology, we have a scheduled program for biofeedback that allows us to monitor our patients and ensure that pelvic floor strengthening and clinical improvement is achieved.

URODYNAMIC STUDY (UDS)

This is a test that measures the pressure in the bladder and the flow of urine through the urethra. It provides information about how much urine the bladder can hold and allows your doctor to assess the efficacy of your bladder in storing and voiding urine. Sometimes, urodynamics is done together with x-ray screening, where live images produced on a TV monitor show the doctor what is happening when your bladder is filling and emptying. The screening is known as video-urodynamics (VUDS). Both routine (without x-ray) and video-urodynamics involve the insertion of very fine tubes into the urethra and rectum. The study forms part of the total assessment of your bladder problems from which your doctor can plan appropriate therapy.

Return

Stress Incontinence

After pregnancy or childbirth, one in three women experience urinary leak when they exert themselves.It can happen while coughing, sneezing or during exercise, running after a bus, laughing loudly with friends or carrying your child. This is due to a weakened bladder support and urinary sphincter. It is the most common type of incontinence affecting younger and middle-aged women.

Patients with mild symptoms are often taught pelvic floor muscle training as a first option. Pelvic muscle exercises (also known as Kegel exercises) are designed to help strengthen weak pelvic muscles around the bladder. Patients are personally supervised to ensure that the exercises are performed properly and are advised to do the exercises consistently for a minimum period of 2 months before results are seen. Performed consistently, significant improvement is experienced by up to 70% of patients.

Patients unable to learn how to do their exercises properly are usually taught using biofeedback and/or electrical stimulation of their pelvic muscles.

There are more than 200 types of surgery to correct stress incontinence. Some were industry driven fads that did not work and others have not withstood the test of time. Currently, the 3 main forms of surgery that have proven long term success are the Burch coloposuspension, the pubovaginal sling and the subrethral slings. All 3 operations seek to resuspend the loosened pelvic floor and provide a firm backing against which the urethra is squeezed during a cough, laugh or sneeze. Of these, the most commonly performed currently is the suburethral sling as they are minimally invasive, can be performed as a day procedure and have the least down time. Suburethral slings like the tension free vaginal tape (TVT) offers excellent cure rates.

These diagrams show how the “hammock” or “backing” afforded by the pelvic floor tissue under the urethra has lost its tone or integrity. So when one coughs, laughs or strains in any way, the transmitted pressure is not contained and urine is allowed to leak. If the sphincter area is especially weak, the leak is even worse.

Mean Op time

Resume voiding

Mean Hosp Stayd

Resume work

TVT

22-42min

6-24H

0.3-3d

10-21d

Burch

72min

70-115H

5-8

42d

PVSling

-

-

16d

42d

A comparison of downtime between the various continence procedures:

Short term cure

Medium term cure

Long term cure

TVT

80-100%

80-95%

80-95%

Burch

84-100%

84(77-89)%

84(79-88)%

PVSling

64-100%

82(73-89)%

83(75-88)%

A comparison of cure rates between the various procedures

Continence issues in the elderly

Urinary incontinence is quite common in the elderly. It can be embarrassing and socially crippling for the patient and leads to hygiene issues at home. Incontinence is the commonest reason for institutionalising the elderly. There are many forms of incontinence but one of the commonest in the elderly is the inability to control their bladder at night or on the way to the washroom. Cure or significant improvement can be achieved with a combination of medication and bladder training. Another common cause is the onset of senile dementia. In such cases, there are simple aids to help caregivers cope.

Post prostatectomy Incontinence

One of the side effects of a radical prostatectomy is urinary incontinence. This takes many forms and patients need to be fully assessed before a treatment plan can be formulated. Post prostatectomy incontinence is worst immediately after the operation and takes up to a year to get better and stabilize. A combination of treatments is available to help patients achieve continence earlier. Continence aids are also available to help patients cope in the meantime. A urodynamic testing is usually required to determine the best treatment option as post prostatectomy incontinence can be quite complex. The best results are also obtained if treatment is started earlier. In severe cases where the urinary sphincter complex is damaged, surgical options are available to augment or replace the damaged sphincter.

Young men with bladder control and voiding problems (Lower urinary tract symptoms)

Some men between 20 to 50 experience symptoms like urinary frequency, a sense of incomplete emptying, urgency and poor bladder control, weak or staccato urinary flow or initial difficulty when trying to empty their bladders. These symptoms are known as lower urinary tract symptoms (LUTS) and are often misdiagnosed as prostatitis and overactive bladders. Patients are often times given repeated courses of antibiotics without much relief. The actual causes can be as varied as bladder neck dysfunction, weak bladder muscles, dysfunctional voiding or overactive bladders. In rare cases, some patients are found to have hitherto undiagnosed spinal abnormalities.

This is one of Dr Quek's areas of interest and we have a wealth of experience in treating young men with the above symptoms. By assessing one's voiding habits, urinary flow and performing a video urodynamic study a more accurate diagnosis and treatment plan can usually be reached.

Continence aids and appliances

For people who are currently participating in a treatment programme or whose urinary incontinence cannot be cured, there are many absorbent products and devices that are available to help patients and caregivers cope:

  • Containment Devices: Pants, pads or pouches with absorbent lining that can contain 150 to 2300 ml of urine.

  • Collection Device : For those with mobility problems who cannot get to the washroom in time

  • Bed Protection : For bed wetters and those who "overflow" at night

  • Catheters : For those unable to empty their bladders completely

  • Others eg night alarms, female urinals